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In vitro cosmetics effectiveness and safety

Eficacia y seguridad in vitro de cosméticos

We are experts in evaluating the effectiveness and safety of cosmetics with cell and tissue models (ex vivo), which permits us to reproduce fast and reliable predictive systems at lab-scale.

We undertake customised studies of the mechanisms of action of an active substance and studies based on conventional protocols according to international guidelines.

 

 

 

Our lines of technological activity:

Toxicity tests
  • Ocular irritation:
    • Haemolysis assay, Invittox no. 37.
    • Assay using a model of reconstituted human skin
    • Fluorescein leakage test method
  • Dermal irritation OECD 404; OECD 439
  • Dermal corrosion OECD 431; OECD 435
  • Nasal irritation
  • Oral irritation
  • Phototoxicity OECD 432
  • Cytoxicity:
    • Mtt
    • Xtt
    • Neutral red
    • Alamar blue
    • LDH
    • MTS
    • Wst-8
Genotoxicity
  • Ames Test OECD 471
  • Mouse lymphoma assay OECD 476
  • Micronucleus test OECD 487
  • Comet assay
Effectiveness Testing
  • Cleaning effectiveness
  • Anti-angiogenic effectiveness
  • Anti-inflammatory effectiveness
  • Antioxidant effectiveness
  • Cell proliferation assay
  • Cell cohesion assay
  • Anti-itch effectiveness
  • Lipolytic effectiveness
  • Collagen synthesis increase assay
  • Elastin synthesis assay
  • β-defensin synthesis increase assay
  • Epidermal proteases liberation assay
  • Metalloprotease decrease assay
  • Anti-growth factor action assay
  • Human cathelicidin level decrease assay.
  • Healing effectiveness
  • Thermal-protection effectiveness
  • Repair and regeneration effectiveness
  • Effectiveness of anti-protection against dryness
  • Hydrating effectiveness
  • Antimicrobial effectiveness
Other cosmetics assays
  • Dermal absorption and penetration OECD 428
  • Challenge test
  • Microbiological controls
  • Determination of active substances by chromatography
  • Development and validation of analytical methods
  • Nanotoxicology

© 2017 GAIKER Technology Centre

Parque Tecnológico, Ed. 202. 48170 Zamudio (Bizkaia) SPAIN

T.: +34 94 6002323, F.: +34 94 6002324

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